INDIANAPOLIS — Simona de Silvestro encountered fire again Tuesday. This time it ended better than her two previous encounters.

De Silvestro’s car erupted in flames during the third practice session for the Indianapolis 500. She escaped unharmed, but the loss of the No. 29 Andretti Autosport Honda will make her effort to qualify for the May 24 race more difficult.

“It’s really frustrating that it seems like fire follows me,” de Silvestro said. “Maybe this time is third time’s the charm, and hopefully the team can get the car back together as quickly as possible.”

De Silvestro exited Turn 2 shortly after 2 p.m. ET when smoke began billowing from the rear of the car. As she slowed on the backstretch, flames could be seen coming from the engine cover on the right rear of the car. By the time she stopped at the start of the pit entrance just short of Turn 3, the rear of the car was fully engulfed.

Andretti Autosport engineers blamed the fire on a leak in the fueling buckeye.

“Until now, everything was working fine,” de Silvestro said. “It’s just annoying because it’s a pretty big setback for us, but I have four great teammates, and that will make it easier for us to continue moving forward.”

De Silvestro was not injured, nor was a safety worker who fell while trying to help her get away from the burning car. Minutes after the incident, she was back in the Andretti pit discussing the incident with crew members.

It was the third time de Silvestro encountered fire during an IndyCar race, and the second time at Indianapolis Motor Speedway. In 2010, she was trapped in her car as it began to burn after a crash at Texas Motor Speedway. In 2011, her car flipped and caught fire during practice for the Indy 500.

In both crashes, de Silvestro sustained burns to her hands. She returned to qualify 23rd for the 2011 Indy 500 with both hands bandaged and wrapped. She finished 31st in the race.

It wasn’t immediately clear how Andretti Autosport, which also is fielding cars at Indy for Marco Andretti, Ryan Hunter-Reay, Carlos Munoz and Justin Wilson, would replace de Silvestro’s car.

“It’s definitely unfortunate because the car is pretty burnt down,” de Silvestro said.